Integrating Research into Outbreaks: How can we prepare for the next Marburg outbreak?

10 March 2023

Date: 10 March, 2023

Time: 14:00 CET

 

The WHO R&D Blueprint organized a consultation with the MARVAC partners and focal points from at-risk countries to discuss Marburg vaccine and therapeutic candidates and integrating research during an outbreak.

Agenda

1- Outbreak sit rep including diagnostics and epidemiology
2- Review of core trial protocols for vaccines and therapeutics
3- Panel discussion from at-risk country focal points

 

PRESENTATIONS

Current epidemiological situation of the outbreak in Equatorial Guinea and outbreak response  

Marburg reference laboratory Lab procedures and results from Equatorial Guinea 

Session 1.  Review of evidence and prioritization of candidate vaccines 

Candidate vaccines developers’ update:

WHO Expert Group on vaccines prioritization update 

Session 2. Access to investigational vaccines already in internationally transferable vials 

Ongoing efforts to fund investigational vaccines already in internationally transferable vials.  

Session 3. Towards agreed trial platforms and simple protocols for vaccine studies 

A Phase 1 /2 /3, randomized trial to evaluate the safety, tolerability, immunogenicity, and efficacy of vaccine candidates against Marburg disease.

Review and pre-approval of proposed protocols: How can the NRAS and Ethics committees from at-risk countries facilitate this via the AVAREF mechanisms?

Session 4. Towards agreed trial platforms and simple protocols for therapeutics studies? 

Candidate therapeutics developers’ update:

Towards a pan-filovirus therapeutics protocol - Potential designs and proposed next steps

Main conclusions