Cross-sectional seroepidemiologic study of MERS-CoV infection in high-risk populations in contact with dromedary camels

Overview

Representative serologic studies are designed to collect data to estimate prevalence of antibodies to a new pathogen in a population. This information is critical to better understand the extent of infection in a population and the severity of the new virus.

This study protocol outlines methods to collect data to measure the seroprevalence of cross-reactive antibodies to MERS-CoV in presumed high-risk human populations and to detect viral shedding in dromedary camels in selected countries with high densities of dromedary camel populations.

The study focuses on occupational risk - individuals whose work requires direct and prolonged contact with dromedary camels - and has been adapted for consideration in African and South Asian countries.

The original protocol was published in 2013 and has been updated to reflect updated scientific knowledge about MERS-CoV, the results and experiences of similar studies conducted in a number of countries and input from the FAO and the animal sector.

High risk group questionnaires:

• Camel farm / barn / ranch worker
• Animal market worker-actor
• Quarantine manager-owner
• Quarantine worker
• Abattoir manager / owner
• Abattoir worker