WHO/BS/2023.2463 WHO Reference Reagent for antibodies to Ross River virus

Ross River virus (RRV), the causative agent of epidemic polyarthritis or Ross River fever, is member of the Alphavirus genus in the Togaviridae family and is transmitted by a variety of mosquito vectors (Chen et al., 2018; Yuen et al., 2021). The virus is enveloped, with a positive sense, single-stranded RNA genome (~11.8 kb) that encodes non-structural and structural proteins in two separate open reading frames (Chen et al., 2018).