Mental Health, Brain Health and Substance Use
Our work involves mental health promotion and the prevention of mental, neurological and substance use disorders. We support the expansion of access to affordable, quality care for everyone who needs it.
Combination of two or more antipsychotic medications for psychotic disorders
[2012]
Recommendation(s)
Routinely, one antipsychotic should be prescribed at a time in individuals with psychotic disorders (including schizophrenia).
Strength of recommendation: STRONG
Quality of evidence: VERY LOW
For individuals with psychoses (including schizophrenia) who do not respond to adequate dose and duration of more than one antipsychotic medicine (using one medicine at a time), antipsychotic combination treatment may be considered by primary health care professionals preferably under the supervision of mental health professionals with close clinical monitoring.
Strength of recommendation: CONDITIONAL
Quality of evidence: VERY LOW