Mental Health, Brain Health and Substance Use
Our work involves mental health promotion and the prevention of mental, neurological and substance use disorders. We support the expansion of access to affordable, quality care for everyone who needs it.

Duration of antipsychotic treatment in individuals with a first psychotic episode

2023 updated

Maintenance therapy with antipsychotic medicine for a minimum of 7–12 months should be offered in adults with a first episode of psychosis (including schizophrenia) in remission, carefully balancing effectiveness, side-effects and individual preference.
Strength of recommendation: STRONG
Certainty of evidence: MODERATE

[2012]

Recommendation(s)

In individuals with a first psychotic episode with full and sustained remission, antipsychotic treatment should be continued for at least 12 months after the beginning of remission. Any further continuation of antipsychotic drug treatment should be based on clinical review preferably by a mental health specialist and taking into account the preferences of the individuals, in consultation with the family.
Strength of recommendation: STRONG
Quality of evidence: VERY LOW