2023 updated

Oral antipsychotic medicines – namely aripiprazole, olanzapine, paliperidone, quetiapine, risperidone – should be considered under specialist supervision for adolescents with psychotic disorders (including schizophrenia), carefully balancing effectiveness, side-effects and individual preference.
Strength of recommendation: CONDITIONAL
Certainty of evidence: LOW

Clozapine should be considered for adolescents with a treatment-resistant psychotic disorder (including schizophrenia) under specialist supervision, carefully balancing effectiveness, side-effects and individual preference.
Strength of recommendation: CONDITIONAL
Certainty of evidence: LOW

Recommendation(s)

In adolescents with psychotic disorders (including schizophrenia and bipolar disorder) certain second-generation antipsychotic medications (aripiprazole, olanzapine, quetiapine, risperidone, ziprasidone) can be offered as a treatment option under supervision of a specialist.

If treatment with one of the above agents is not feasible, first-generation antipsychotics (haloperidol, chlorpromazine, perphenazine, molindone) may be used under supervision of a specialist.
Strength of recommendation: VERY LOW
Quality of evidence: CONDITIONAL